Sean ‘Diddy’ Comb’s longtime protégée, Dia Simms, is stepping down as president of the hip-hop mogul’s Combs Enterprises, Page Six has exclusively learned.

“She’s leaving the business to enter the cannabis industry,” an insider told us.

Simms has been with Diddy for nearly 15 years and oversaw his lucrative liquor deals that include Cîroc vodka and DeLeón tequila.

She started out as his assistant when she joined the company in 2005.