Jennifer Lopez hits the road with Renée Zellweger and Eddie Murphy — while dreaming of a new life far away from America.

Jenny from the Block admitted that she would “love to live somewhere other than the United States” as she posed straddling a motorbike alongside her fellow stars on the cover of Vanity Fair’s 26th annual Hollywood issue, which hits newsstands Jan. 23.

The 50-year-old Bronx-born actress is all black, with a striking, cleavage-baring jacket, leather-style cap, and gloves in the cover shot by Ethan James Green.

A besuited Murphy, 58, smiles while in the driver’s seat of the bike beside Lopez, with Zellweger, 50, holding on from behind in a black-and-white patterned frock. The actors also appear in evening wear for a cover spread.

Vanity Fair’s Editor in Chief Radhika Jones said the Hollywood power trio was chosen out of the 23 stars profiled by the mag because of their “versatility, persistence, and sheer scope of talent.”

“They are road warriors, not just of this season but of our era, and we’d follow them down any highway,” Jones said.

The shoot represented them taking a road trip to Hollywood — even though J.Lo clearly wishes she could travel overseas.

“I would love to live somewhere other than the United States, in a small town in Italy, or on the other side of the world, in Bali,” she admitted to the mag, calling it a “bucket list” aspiration.

“Find another life where it’s a little bit more simple and organic and where I get to ride a bike, and buy bread, and put it in my basket, and then go home and put jelly on it, and just eat and paint, or sit in a rocking chair where there was a beautiful view of an olive tree or an oak tree and I could just smell.

“I have fantasies like that,” she admitted.

The “Hustlers” star also spoke of how “empowering” it was to wear her eye-popping Donatella Versace dress almost 20 years after she first made a splash with it at the 2000 Grammys.

“I think for women, knowing you can put on a dress 20 years later — it resonated. It was like, ‘Yes, you know, life is not over at 20!’” she said.

She also admitted to extreme regret at passing up the role in 2002’s “Unfaithful” that ultimately went to Diane Lane.

“I want to literally, like, shoot my toe off. I do,” she told the mag.

Murphy, meanwhile, said he stepped away from acting for eight years because he had “gotten to the point where I was just so burned out on the process of making a movie that if I was a little boy, I would have started crying.”

He also said he took a cue from seeing the deaths of other stars from his generation, noting Michael Jackson, Prince and Whitney Houston.

“What they had in common was that their career, their life as artists, was all-consuming,” he said.

“The center of their whole s–t revolved around them as artists, and everything else suffered as a result,” he said. “That’s the recipe for an early exit.”

Other stars featured in the special issue include Antonio Banderas, Lily-Rose Depp, Florence Pugh, Daniel Kaluuya, Laura Dern, Willem Dafoe, and Jennifer Hudson.