Drew Barrymore has made the leap from movie star to TV stunner to talk show host. The Drew Barrymore Show premiered on September 14 and has already got Twitter talking. Between the socially distanced set, the seemingly small but enthusiastic audience, and segments that feel very on-brand Barrymore, there's a lot to react to.

Here's a taste of The Drew Barrymore Show as seen by Twitter users:

GOOD MORNING GAYS: drew barrymore, lucy liu and cameron diaz reunited 🚨 pic.twitter.com/Z9kgMwiT5G

— Cole Delbyck (@coledelbyck) September 14, 2020

pic.twitter.com/salJCvbY3n

— Cole Delbyck (@coledelbyck) September 14, 2020

God she ended Ellen for good pic.twitter.com/h3CdUcHqjD

— ... (@memwnto) September 14, 2020

This is the loudest the room has been?? 😂

— TheNewBurr (@BurrNew) September 14, 2020

The laws of physics walked so the Drew Barrymore Show could run pic.twitter.com/aH4LMOkc3D

— tristan (@trjstn) September 14, 2020

I DIDNT WANNA START CRYYING HERE--- i love them so much omg and i'm loving the vibe of this new Drew Barrymore talk show.....definitely needs to replace all other daytime talkshow spots 👀 pic.twitter.com/eIrstIcPK8

— Maybe: Dan Radiance (@D_Radiance) September 15, 2020

pic.twitter.com/6ShyILBew3

— diegopinzonbrazil (@diegopinzonbr) September 14, 2020

That remarkable sentence will go down as one of the great pieces of work of this generation. #speechless

— Alfy (@AlfyJC) September 16, 2020

Drew Barrymore's new show is unhinged and I cannot get enough of it pic.twitter.com/Qqh8v9HdUP

— Ryan Bloomquist (@ryanbloomquist) September 16, 2020

Here's the latest clip that has many jaw-dropped: Drew Barrymore talks snakes and celibacy.

I can't get over how bad Drew Barrymore's talk show is pic.twitter.com/qvYMcu8AWX

— JACQUES (@arcadeyblog) September 15, 2020

Oh Drew... pic.twitter.com/ASFCJQQQIU

— becky 🏴󠁧󠁢󠁳󠁣󠁴󠁿 (@ohhiyabecky) September 15, 2020

obsessed https://t.co/p8YWj2LFaD

— wabba rangadoon (@uncletalia) September 16, 2020

I don't think that's why it's awkward.

— CookieKidOnDuty (@JordanHarkins6) September 16, 2020

I like how the writers keep the set-ups and punchlines socially distanced.

— Hattori Hanzo Moleman (@HanzoMoleman) September 16, 2020

I liker her, so I liked it. Not all comedy is for everyone ❤️

— MadameTerribadger (@tmbline) September 17, 2020

This is what happens when you cancel Santa Clarita Diet

— dave garrett sarrafian (@strangedove) September 17, 2020

Actually I love it, this is the maximum amount of Drew Barrymore and she's definitely playing into it https://t.co/N0bjPwEac7

— lilah (@dvnots) September 16, 2020