Perhaps the most dramatic “Grey’s Anatomy” exit occurred when Katherine Heigl left the show. Even though we said goodbye to Izzie Stevens in 2010, the drama with Heigl, 41, began in 2008 when she controversially told the Los Angeles Times (via The New York Times) that she’d withdrawn her name from the Emmy contenders list.

“I did not feel that I was given the material this season to warrant an Emmy nomination,” she said. “In addition, I did not want to potentially take away an opportunity from an actress who was given such materials.”

There had already been rumors at the time that she’d been trying to get out of her contract, but she would continue playing the part until 2010, when she confirmed she was “done.”

Two years later, Shonda Rhimes finally commented on Heigl’s interview about the Emmys, saying, “On some level, it stung and on some level I was not surprised.” Then in 2014, while discussing her hit show “Scandal,” Rhimes doubled down on her comments. “There are no Heigls in this situation,” she told The Hollywood Reporter, adding of her “no a–hole” policy, “I don’t put up with bulls–t or nasty people. I don’t have time for it.”

Heigl, who says she immediately apologized to Rhimes for her comments, told Howard Stern in 2016 that the fallout led her to seek therapy. “I was not handling it well. I was feeling completely like the biggest piece of s–t on the bottom of your shoe. I was really struggling with it and how to not take it all personally and not to feel that there’s something really deeply wrong with me,” she said.

Heigl starred in some films, and she is still acting pretty consistently. Most recently, she appeared on the final season of “Suits” after Meghan Markle left the show and is starring alongside Sarah Chalke in Netflix’s adaption of Kristin Hannah’s novel “Firefly Lane,” which is set to come out sometime this year.